- Known allergy to plastic, biomaterial, non-absorbable fillers
- Active acne or skin infection
- Keloid predisposition
- Auto-immune diseases: scleroderma, sarcoidosis, amyloidosis, etc.
- Anti-coagulant medication e.g., Warfarin
- Haemophilia
- Uncontrolled Hypertension
- Severe diseases
- Collagenosis (collagen-vascular disease)
- Neurological and mental disorders
- Pregnancy, breastfeeding
- Malignancy/Chemotherapy
- Hepatitis B & C, HIV
- Porphyria
